基因疗法在骨科运动医学中的应用   总被引：1，自引：0，他引：1  

王晔平  陈国庆  张弛  胡声宇 《武汉体育学院学报》2003,37(1):50-52

基因疗法是一种新的有潜力的治疗方法，几乎在各个医学领域中都有其不同的应用。至今为止，几乎所有骨科运动医学的研究都已使用了标志基因，主要是E.colilacZ基因。基因疗法存在的问题时转染细胞的表达时间有限以及不完全了解对基因表达的控制。即使基因表达的时间有限，但这项技术仍有可能运用于运动医学领域，可能成为急性损伤治疗的先进方法，在软骨、半月板、肌腱和韧带中转基因的成功会给运动损伤的治疗带来新的希望。  相似文献   

肘关节内侧副韧带损伤机理及临床意义     

王乔君  陆勇 《中国体育科技》2002,38(12):46-47

观察治疗肘内侧副韧带断裂 5 8例 ,用不同方法缝合 ,探讨肘关节内侧副韧带损伤及其临床意义。结果 :随防 1年 6个月～ 6年 ,49例恢复良好 ,肘关节侧向稳定。结论 :肘关节内侧副韧带断裂宜早期手术 ,恢复和保持肌起点和韧带断端的正常接触。  相似文献   

CybexⅡ~+测试中膝关节腘绳肌与股四头肌力矩峰值比率问题初探   总被引：5，自引：0，他引：5  

潘启强 《体育科学》1992,(1)

对不同运动项目的男女青少年运动员84人进行CybexⅡ~+等速膝关节屈伸测试,发现随着测试速度的提高,腘绳肌与股四头肌力矩峰值比率也相应上升。各项目上升幅度有所不同:以膝关节伸屈动作为主、腿部动作负荷愈大、动作速度愈快的项目,该比率上升幅度愈大。  相似文献   

Investigation of angiogenesis genes with anterior cruciate ligament rupture risk in a South African population     

Masouda Rahim  Hayden Hobbs  Willem van der Merwe  Michael Posthumus  Malcolm Collins 《Journal of sports sciences》2018,36(5):551-557

The angiogenesis-signalling pathway is a physiological response after mechanical loading to promote matrix remodelling and thereby maintain tissue homeostasis. Studies have shown increased expression of angiogenic molecules in response to loading and in ruptured ligaments. Recently, polymorphisms within the vascular endothelial growth factor A (VEGFA) and kinase insert-domain receptor (KDR) genes were associated with risk of anterior cruciate ligament (ACL) ruptures and Achilles tendinopathy in Caucasian study groups. A case-control genetic association study was conducted on 100 controls and 98 participants with surgically-diagnosed ACL ruptures; of which 51 participants reported non-contact mechanism of injury (NON). All participants were genotyped for five functional polymorphisms: VEGFA (rs699947, rs1570360, rs2010963) and KDR (rs2071559, rs1870377). Haplotypes were inferred. In the male participants, the KDR rs2071559 AG genotype was significantly over-represented (P = 0.048, OR: 1.90, 95% CI: 1.00–3.59) in the controls. Furthermore, the GG genotype was significantly under-represented in the male controls compared to the male ACL group (P = 0.018, OR: 2.77, 95% CI: 1.17–6.55) and the male NON subgroup (P = 0.013, OR: 3.26, 95% CI: 1.24–8.58). Haplotype analysis implicated the KDR gene in all participants and in male participants separately. Collectively, these results implicate the angiogenesis-signalling pathway as a potentially key biological pathway contributing to ACL injury susceptibility.  相似文献   

The effect of high intensity exercise and anticipation on trunk and lower limb biomechanics during a crossover cutting manoeuvre     

Enda F. Whyte  Chris Richter  Siobhan O’connor  Kieran A. Moran 《Journal of sports sciences》2018,36(8):889-900

We investigated the effects of high intensity, intermittent exercise (HIIP) and anticipation on trunk, pelvic and lower limb biomechanics during a crossover cutting manoeuvre. Twenty-eight male, varsity athletes performed crossover cutting manoeuvres in anticipated and unanticipated conditions pre- and post-HIIP. Kinematic and kinetic variables were captured using a motion analysis system. Statistical parametric mapping (repeated-measures ANOVA) was used to identify differences in biomechanical patterns. Results demonstrated that both unanticipation and fatigue (HIIP) altered the biomechanics of the crossover cutting manoeuvre, whereas no interactions effects were observed. Unanticipation resulted in less trunk and pelvic side flexion in the direction of cut (d = 0.70 – 0.79). This led to increased hip abductor and external rotator moments and increased knee extensor and valgus moments with small effects (d = 0.24–0.42), potentially increasing ACL strain. The HIIP resulted in trivial to small effects only with a decrease in internal knee rotator and extensor moment and decreased knee power absorption (d = 0.35), reducing potential ACL strain. The effect of trunk and hip control exercises in unanticipated conditions on the crossover cutting manoeuvre should be investigated with a view to refining ACL injury prevention programmes.  相似文献